久坐與不良健康轉歸有關。既往研究主要是依賴自我報告數據，尚缺乏客觀檢測到的久坐時間與心髒代謝生物指標相關性的數據，尤其是在西班牙裔和拉丁裔美國人中。美國學者們近期在上述人群中開展了一項基於人群的相關研究，結果表明，久坐時間和心髒代謝生物指標間存在有害的關係，這種相關性獨立於體力活動。研究結果強調了減少久坐時間對於預防心血管代謝性疾病的重要性，即使是在那些滿足體力活動推薦量的人群中。相關論文近期在線發表於《循環》(Circulation)雜誌。

研究者們通過運動加速器客觀檢測了“西班牙社區健康研究/拉丁裔研究”中來自美國4個城市12083例18-74歲人群久坐時間和多種心髒代謝生物指標的相關性。久坐時間(<100計數/分鍾)被標準化到的佩戴時間16小時/天。平均久坐時間為11.9小時/天。

結果顯示，校正中度至劇烈體力活動和混雜變量後，久坐時間延長與高密度脂蛋白膽固醇(HDL-C)減少有關(P=0.04)，還與甘油三酯水平、餐後2小時血糖和餐後血胰島素水平以及胰島素抵抗指數增加有關(所有P值均<0.0001)。這些相關性在不同年齡、性別、西班牙裔和拉丁裔背景以及體力活動水平下依然存在普遍的一致性。即使是在那些滿足指南推薦體力活動量的個體中，久坐時間也與若幹心髒代謝生物指標(舒張壓、HDL-C、空腹和餐後2小時血糖、空腹血胰島素和胰島素抵抗指數，所有P值均<0.05)存在有害的關係。

參考文獻：Qibin Qi,et al.CIRCULATIONAHA.115.016938Published online before print September 28, 2015,doi: 10.1161/CIRCULATIONAHA.115.016938

Objectively-Measured Sedentary Time and CardiometabolicBiomarkers in U.S. Hispanic/Latino Adults: The HispanicCommunity Health Study/Study of Latinos (HCHS/SOL)
1. Qibin Qi1*;
2. Garrett Strizich1;
3. Gina Merchant2;
4. Daniela Sotres-Alvarez3;
5. Christina Buelna2;
6. Sheila F. Castañeda2;
7. Linda C. Gallo2;
8. Jianwen Cai3;
9. Marc D. Gellman4;
10. Carmen R. Isasi1;
11. Ashley E. Moncrieft4;
12. Lisa Sanchez-Johnsen5;
13. Neil Schneiderman4;
14. Robert C. Kaplan1
-Author Affiliations
1. 1Albert Einstein College of Medicine, Bronx, NY
2. 2San Diego State University, San Diego, CA
3. 3University of North Carolina, Chapel Hill, NC
4. 4University of Miami, Miami, FL
5. 5University of Illinois at Chicago, Chicago, IL
1. ↵* Department of Epidemiology and Population Health, Albert Einstein College ofMedicine, 1300 Morris Park Avenue, Bronx, NY 10461 qibin.qi@einstein.yu.edu
Abstract
Background—Sedentary behavior is recognized as a distinct construct from lackof moderate-vigorous physical activity and is associated with deleterious healthoutcomes. Previous studies have primarily relied on self-reported data, while data on the relationship between objectively-measured sedentary time andcardiometabolic biomarkers are sparse, especially among U.S.Hispanics/Latinos.
Methods and Results—We examined associations of objectively-measured sedentary time (via Actical accelerometers for 7 days) and multiplecardiometabolic biomarkers among 12,083 participants, aged 18-74 years, from the Hispanic Community Health Study/Study of Latinos.Hispanics/Latinos of diverse backgrounds (Central American, Cuban, Dominican, Mexican, Puerto Rican, and South American) were recruited from 4 U.S. cities between 2008 and 2011.
Sedentary time (<100 counts/minute) was standardized to 16-hour/day of wear time. The mean sedentary time was 11.9 hours/day (74% of accelerometer wear time). After adjustment for moderate-vigorous physical activity and confounding variables, prolonged sedentary timewas associated with decreased high-density lipoprotein (HDL)-cholesterol (P=0.04), and increased triglycerides, 2-hour glucose, fasting insulin and HOMA-IR (all P<0.0001). These associations were generally consistent across age, sex,Hispanic/Latino backgrounds, and physical activity levels. Even amongindividuals meeting physical activity guidelines, sedentary time was detrimentally associated with several cardiometabolic biomarkers (diastolic blood pressure, HDL-cholesterol, fasting and 2-hour glucose, fasting insulin and HOMA-IR; allP<0.05).
Conclusions—Our large population-based, objectively-derived data showed deleterious associations between sedentary time and cardiometabolic biomarkers, independent of physical activity, in U.S. Hispanics/Latinos. Our findings emphasize the importance of reducing sedentary behavior for theprevention of cardiometabolic diseases, even in those who meet physical activity recommendations.