近日，根據8月28日在線發表在《Head &Neck》雜誌上的一篇文章表明，研究發現幽門螺杆菌(H.pylori)感染可增加喉鱗狀細胞癌的發生機率，但研究發現幽門螺杆菌(H. pylori)感染對鼻咽癌基本無影響。

　　中國複旦大學醫學院Zhou Jian 博士和他的同事們對幽門螺杆菌的感染作用進行了一項係統回顧性相關研究，本次回顧性研究旨在研究有關咽喉癌患者中幽門螺杆菌的感染情況。通過一係列整理分析，本次分析所得數據一共來自11項相關研究的結果，最後，研究人員應用該數據進行了meta分析。

　　在本項研究中研究人員發現，在研究幽門螺杆菌感染的過程中，最終得出的實驗結果發現，與正常對照組相比，實驗組中幽門螺杆菌含量有明顯升高跡象，(比值比為2.87；95%置信區間內1.71比4.84；P <0.0001)。喉鱗狀細胞癌和鼻咽癌的比值比分別為3.28(95%置信區間，1.91比5.63；P <0.0001)和1.35(95%置信區間，0.86比2.12；P = 0.188)。

　　“這個meta分析結果有力的證明了有關幽門螺旋杆菌感染與咽喉癌之間存在聯係，特別是通過聚合酶鏈反應(PCR)和酶聯免疫吸附試驗(ELISA)進行確證後。”作者寫道。“然而，通過分析發現幽門螺旋杆菌感染和鼻咽癌之間沒有發現明顯的關聯跡象。此外，少量參與這項研究的項目在這個評估中引起了較大的置信區間。”

　　doi:10.1002/hed.24214

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Association between helicobacter pylori infection and carcinoma of the larynx or pharynx

　　Jian Zhou PhD, Duo Zhang PhD, Yue Yang MD, Liang Zhou PhD andLei Tao PhD*

　　Background Infection with Helicobacter pylori (H. pylori) plays a role in the development of gastric carcinoma. However, there is controversy as to whether H. pylori infection increases laryngeal or pharyngeal cancers. Methods We managed a systematic review of researches related to H. pylori infection in laryngeal or pharyngeal carcinomas, distributed up to December 2014. Odds ratios (ORs) and 95% confidence intervals (CIs) were assessed by random effects models or according to heterogeneity I2. Results Eleven studies were involved in the meta-analysis. Overall, H. pylori infection was significantly higher in the study group compared with the normal control group (OR = 2.87; 95% CI = 1.71–4.84; I2 = 67.1; p <.0001, random effects analysis). The ORs for laryngeal carcinoma were 3.28 (95% CI = 1.91–5.63; I2 = 58; p <.0001, random effects model). The ORs for pharyngeal cancer were 1.35 (95% CI = 0.86–2.12; p = .188, random effects model). Conclusion This study supported the proposition that infection with H. pylori was related to laryngeal carcinoma, specifically in the hospital-based control group and diagnosed bypolymerasechain reaction (PCR) or enzyme-linked immunosorbentassay(ELISA). Nevertheless, no significant relationship was discovered between H. pylori infection and pharyngeal cancer. 2015 Wiley Periodicals, Inc. Head Neck, 2015