摘要：目的：本研究的目的在於探討抗著絲點(ACA)抗體和抗SSA/Ro抗體雙陽性的幹燥綜合征患者的特點，確定這些抗體陽性的臨床意義。

方法：我們共納入108例進行了唇腺活檢的幹燥綜合征患者(6例男性，平均年齡57.9歲)。根據ACA和anti-SS-A/Ro抗體陽性將患者分為4組。比較各組患者症狀、實驗室及病理數據及硬皮病相關資料。

結果：納入的幹燥綜合征患者中共有16例ACA/SS-A雙陽性，20例ACA單陽，67例SS-A單陽，5例ACA/SS-A雙陰性。ACA/SS-A 雙陽性的患者年齡明顯高於SS-A 單陽的患者(平均年齡71.1 vs 53.1歲)。與ACA單陽的患者相似，抗體雙陽性的患者在診斷時具有更高的EULAR 幹燥綜合征疾病活動性指數評分(ESSDAI) (平均3.81 vs 0.50) 和更高的血清IgG 水平(平均2,009 vs 1,389 mg/dL)。隨訪45.6個月內(範圍: 1-178)，無1例患者出現皮膚硬化表現。

結論：這些結果顯示, ACA/SS-A雙陽性的幹燥綜合征患者不同於ACA單陽和SSA單陽的患者。臨床實踐中，ACA和抗SS-A/Ro抗體雙陽性的幹燥綜合征患者應受到更多關注。

附原文:Abstract OBJECTIVES:The purpose of our study was to define the clinical characteristics of anti-centromere antibody and anti-SS-A/Ro antibody (ACA/SS-A) double positive Sjögren's syndrome (SS) and to clarify the clinical impact of these antibodies.METHODS:We examined 108 patients (6 males, mean age 57.9 years) with SS who underwent labial salivary gland biopsy. The patients were divided into 4 groups by ACA and anti-SS-A/Ro antibody positivity. Symptoms, laboratory and pathological data, and scleroderma-related data were compared among the groups.RESULTS:The cohort consisted of 16 ACA/SS-A double positive, 20 ACA single positive, 67 SS-A single positive, and 5 ACA/SS-A double negative SS. ACA/SS-A double positive SS were significantly older than SS-A single positive SS (mean age 71.1 vs 53.1 years). They had higher EULAR Sjögren's syndrome disease activity index (ESSDAI) at diagnosis (mean 3.81 vs 0.50) and higher serum IgG (mean 2,009 vs 1,389 mg/dL) than ACA single positive SS. No patients developed skin sclerosis during a mean follow-up period of 45.6 months (range: 1-178).CONCLUSIONS:These results demonstrate that ACA/SS-A double positiveSS is distinct from ACA single positive and SSA single positive SS. The combination of ACA and anti-SS-A/Ro antibody in SS should deserve greater attention in clinical practice.

引自：Suzuki Y,Fujii H,Nomura H,Mizushima I,Yamada K,Yamagishi M,Kawano M.Impact of double positive for anti-centromere and anti-SS-A/Ro antibodies on clinicopathological characteristics of primary Sjögren's syndrome: a retrospective cohort study. Mod Rheumatol. 2017 Dec 18:1-19. doi: 10.1080/14397595.2017.1418164.