Rheumatology一刊今日在線發布了一項新研究，攝入過多鈉的吸煙者患上風濕性關節炎的幾率要高出一倍多。

最近動物和人類細胞研究的成果顯示攝入較多鈉與患上風濕性關節炎之間存在聯係。瑞典於默奧大學(Umeå University)風濕病學公共健康和臨床醫學係的Börn Sundström及其同事采用瑞典西博籐省幹預項目(Västerbotten Intervention Programme)數據，進行了巢式病例對照研究，以驗證是否能產生類似結論。研究對386名對象進行觀察，研究對象在飲食習慣列入社區幹預項目平均7.7年後開始風濕性關節炎症狀。作為對比，研究人員還從相同的數據庫中挑出1886個匹配控製樣本進行了聯合分析。

原文標題：Interaction between dietary sodium and smoking increases the risk for rheumatoid arthritis: results from a nested case–control study

原文鏈接：http://rheumatology.oxfordjournals.org/content/early/2014/09/02/rheumatology.keu330.full

作者：Björn Sundström、Ingegerd Johansson、Solbritt Rantapää-Dahlqvist

Abstract

Objective. Recent studies in animal models and on human cells have shown an effect of sodium chloride (NaCl) on Th17 cells promoting inflammation. The aim of this study was to evaluate the impact of NaCl intake on the risk of development of RA.

Methods. A nested case–control study was performed using population-based prospective data from the Västerbotten Intervention Programme. The study included 386 individuals who had stated their dietary habits as part of a community intervention programme a median of 7.7 years before the onset of symptoms of RA. For comparison, 1886 matched controls were identified from the same database and co-analysed.

Results. No significant association was found between sodium intake and the development of RA when all of the individuals were included. In analyses stratified for smoking status at the time of the examination, sodium intake more than doubled the risk for RA among smokers [odds ratio (OR) 2.26 (95% CI 1.06, 4.81)]. This was not observed among non-smokers. Additive interaction analysis of smoking and cases with the highest tertile of sodium intake revealed that 54% of the increased risk of developing RA from these exposures was due to interaction between them [attributable proportion 0.54 (95% CI 0.26, 0.82)]. The risk was further increased for the development of anti-CCP-positive and/or HLA shared epitope–positive RA.

Conclusion. Although we were unable to confirm our stated hypothesis, our results that high sodium consumption among smokers was associated with the risk of RA may provide new insights into the impact of smoking in RA development.